The immune system is a biological structure and processes within an organism that protect against diseases. To function properly ,an immune system must detect a wide variety of agents, from viruses to parasite worms, and distinguish them from the organism’s own health tissues. The effects of ethanol extract of Telfairia occidentalis leaf on the immune system of the wistar albino rats were evaluated. In this study, the experimental rats were divided into four groups made up of four animals each. Group 1 received 100mg/kg and pyrogallol, group 2 received 300mg/kg of the extract and and pyrogallol, group 3 received only pyrogallol (negative control) and group 4 received normal feed for 21days. The result showed a significant increase in hematological parameters of TWBC,RBC and haemoglobin in both dose groups compared to the negative control. Similarly there was a significant increase (p<0.05) in the humoral antibody titer response and delayed type hypersensitivity of rats treated with the extract compared to negative control. There was no significant difference (p>0.05) in the result of the carbon clearance test. The overall results indicated immunostimulatory properties of the plant extract.
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